The Deplin 15 made me super anxious and ragey, (overmethylation?) so I discontinued it. I didn't fill the prescription for the Cerefolin because it costs $4 per pill and is not covered by my insurance.
Instead I researched over the counter options and found Methyl-Life but forgot to actually order anything for a week or so. I ordered the 2.5mg dose, $36 for 90 pills. I decided to start with that level and bump it up to the 5mg dose by taking two pills if it seemed necessary (the CerefolinNAC is 5.6mg of the l-methylfolate for comparison).
I am pregnant (8 weeks or so!) and of course am going to be tired and emotional, but I think without the methylfolate my brain doesn't work as well and my thinking and mood is more negative overall..
Oh, and I'm still mostly grain free, but on Labor Day, I cheated for my brother-in-law's birthday and mother-in-law's famous corn tortilla enchiladas, with beans and rice (she used GF sauce and left the cheese off for me).
That whole week, I really struggled with anxiety. My thoughts went in circles. I was worried about Curly-Q, about DH, about our new house, about the move, about the new baby, about everything!
I don’t think it was a coincidence that that level of anxiety came on the heels of "cheating" with grains at my brother-in-law's birthday party, or that I continued to "cheat" for a few days afterward with the gluten-free chocolate chip cookies left over from Curly-Q’s school birthday party.
Between not having the methylfolate and adding grains/sugar back in, it put me back where I started but maybe even worse because I know now the anxiety and depression/dysthymia I was living with isn't normal, and more importantly, what it's like without it!
So finally the Methyl-Life brand of l-methylfolate came in and after a few days of taking it, I started to feel much better. I started out with the single pill (2.5 mg) dose and then after a few days, increased it to two pills for a 5mg dose.
5mgs is my sweet spot I think. Since starting at that level, I have almost zero anxiety, clear/positive thinking, and an ability to plan ahead and execute tasks. It’s like l-methylfolate gets me to the place where my coping mechanisms work again!